TP53

The body's main tumour-suppressor, often called the “guardian of the genome.” It halts damaged cells before they turn cancerous. Broken TP53 shows up in roughly half of all human cancers.

AlphaMissense matched the confirmed verdict on 251 of 262 mutations (96%). It missed 3 and raised 8 false alarms.

Note: AlphaMissense was trained on ClinVar, so “vs doctors” partly grades it on its own answer key and reads high. The independent check is “vs lab.” why this matters →